Response to antiretroviral therapy in children enrolled in the Columbia MTCT-Plus Initiative

Abrams E.1, Kaytal M.1, Nash D.1, Toro P.1, Coakley E.2, El-Sadr W.1

Introduction: The MTCT-Plus Initiative, currently active in 9 resource-limited countries in sub-Saharan Africa and Thailand, provides comprehensive multidisciplinary HIV care and treatment including antiretroviral (ART) to HIV+ mothers and their HIV-infected children, partners, and household members. We assessed the CD4+ response in children on ART.

Methods: Baseline demographic and CD4+ number and percent pre- and post-ART initiation were analyzed. The relationship between time since ART initiation in weeks and CD4+ count and percent was estimated using linear regression

Results: As of November 2004, MTCT-Plus had included 358 HIV-infected children- 149 (42%) aged 0-18 months, 209 (58%) aged 19 months-15 years; 310 (87%) were ART naive. This analysis included 144 children (49% female) who initiated ART. Median age of children at ART initiation was 19 months (range 2 months – 12 years). Linear regression modeling showed a positive relationship between time post-ART initiation and CD4+. On average, each 6 months on ART was associated with an increase of 129 cells/mm3 and CD4+ of 3.6% (p < 0.0001). This relationship remained after adjustment for gender and age at initiation (p < 0.0001).

Conclusions: HIV-infected children in the MTCT-Plus Initiative who initiated ART had a favorable response as measured by CD4+ count and percent. This suggests that ART use in children will be effective in resource-limited settings and highlights the importance of inclusion of children in HIV treatment programs.

The 3rd IAS Conference on HIV Pathogenesis and Treatment
Abstract no. MoPe11.6C28

Suggested Citation
"AbramsE., et al. Response to antiretroviral therapy in children enrolled in the Columbia MTCT-Plus Initiative. Poster Exhibition: The 3rd IAS Conference on HIV Pathogenesis and Treatment: Abstract no. MoPe11.6C28"